Fig. 7.

α 1D-AR and HCQ docking studies : (a) 3D interaction showing HCQ-bound to the membrane spanning domain of the receptor protein at the orthosteric site (left side– surface view, right side – ribbon representation of protein); (b) Superimposition of α1D-AR and β2-AR (template with 38% similarity), ligand in stick representation, green: HCQ and pink: AR antagonist (c) 3D interaction showing HCQ bound to the membrane spanning domain of the β2-AR protein at the substrate binding site. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)