Table 1.
Predictions by different software of target proteins to which HCQ can bind with high affinity.(The software tool is given in bold and the proteins identified by that tool are listed immediately below).
| SWISS TARGET PREDICTION | TARGETMINE |
|---|---|
| Muscarine acetylcholine receptor M2 | Toll like receptor 7 |
|
Alpha-1D-Adrenergic receptor |
Toll like receptor 9 |
| SEA SERVER |
Cytochrome P450 |
| Muscarine acetylcholine receptor M2 | DRUGBANK/PUBCHEM |
| Alpha-1D-Adrenergic receptor | DNA |
| Histamine N methyltransferase | Toll like receptor7 |
| DNA gyrase subunit B | Toll like receptor 9 |
|
C–C Chemokine receptor type 4 |
Cytochrome P450 |
| PROMISCOUS |
Angiotensin converting enzyme 2 |
| Caspase3 | CHEMBL |
| Caspase 8 | Coagulation factor X |
|
Interleukin-6 |
Carbonic anhydrase |
| SUPERTARGET |
Neuronal acetylcholine receptor alpha7 (Nicotinic acetylcholine receptor) |
| Caspase3 | Acetylcholinesterase |
| Caspase 8 | |
| Interleukin-6 |