Table 7.

Interactions between HCQ-bound ACE2 and Spike proteins: (a) hydrogen bonds, (b) salt bridges.

ACE2-HCQ	DISTANCE (Ao)	SPIKE
Asn 322 [ND2]	2.76	Ser 477 [OG]
Gln 325 [N]	3.16	Ala 475 [O]
Lys 353 [NZ]	2.91	Tyr 453 [OH]
Asp 30 [OD1]	2.76	Gln 498 [NE2]
Asp 30 [OD2]	2.62	Tyr 499 [OH]
Glu 35 [OE2]	2.88	Gly 502 [N]
Glu 35 [OE2]	2.91	Asn 501 [ND2]
Asp 38 [OD1]	2.69	Arg 403 [NH1]
Asp 38 [OD2]	2.71	Arg 403 [NH2]
Lys 353 [O]	2.9	Tyr 453 [NZ]
His 34 [NE2]	2.88	Tyr 505 [O]
ACE2-HCQ	DISTANCE (Ao)	SPIKE
Asp 38 [OD1]	3.55	Arg 403 [NH2]
Asp 38 [OD1]	2.69	Arg 403 [NH1]
Asp 38 [OD2]	2.71	Arg 403 [NH2]
Asp 38 [OD2]	3.45	Arg 403 [NH1]