Figure 2.

Notable skin and subcutaneous tissue volumization through hydration of lateral periorbital area resulting in wrinkle reduction after only two weeks of topical marine nano-collagen (tropocollagen) administration on water moist skin. Hydrophilic nano-collagen binds water (or other agents normally unable to penetrate the epidermal barrier) enabling dermal permeation across the skin (transepidermal and appendageal pathways) and its delivery to dermal layers below. Panel (a) 55 year old female with lateral orbital "crow feet" wrinkling before treatment by nano-collagen, and Panel (b) two weeks after, once a day, application of topical nano-collagen.