Fig. 2.

Lung pathology in SARS-CoV-2-infected hamsters. a, Gross pathology, histopathology (H&E, 40 × , scales bars of 50 µm), and CT findings at 7 days post-infection. Ground glass opacities (GGO) and consolidations were detected by CT scan (pink arrows indicates affected area). b Automated lung segmentation of CT images from a SARS-CoV-2-infected hamster is shown. c Maximum intensity projection of SARS-CoV-2-infected hamster demonstrating the lung (blue) and pneumonic areas (pink). d Whole lung, lung volume above threshold, and CT score for male (n = 15) and female (n = 11) hamsters. While no differences are noted in the whole lung volumes, the lung disease (CT score) was substantially worse in male compared to female animals. Data represented as median ± interquartile range.