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. 2021 Aug 23;24(1):135–143. doi: 10.1007/s11307-021-01638-5

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© World Molecular Imaging Society 2021

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 3 — Pulmonary ¹²⁴I-iodo-DPA-713 PET/CT of SARS-CoV-2-infected hamsters. a Transverse lung sections of a representative hamster imaged with ¹²⁴I-iodo-DPA-713 showing higher uptake within the GGO and pneumonic areas. b ¹²⁴I-iodo-DPA-713 PET activity is higher in pneumonic regions compared to unaffected lung. c DPA-713-IRDye680LT fluorescence co-localizes with the diseased lung. d ¹²⁴I-iodo-DPA-713 PET signal is higher in male versus female hamsters. A VOI was created for each lung lesion (GGO and consolidations) in males (n = 11), females (n = 11) and unnaffected lung (n = 19). Data represented as median ± interquartile range.