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. 2021 Aug 9;12:674642. doi: 10.3389/fgene.2021.674642

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Copyright © 2021 Liu, Ban, El Sergani, Lee, Hecht, Wehby, Moreno, Feingold, Marazita, Cha, Szabo-Rogers, Weinberg and Shaffer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LocusCompare plot at the PRICKLE1 locus for cranial base width. (Left) Joint distribution of the –log₁₀(p-value) from the Levene’s test and the gene-by-gene (G × G) interaction test, colored by linkage disequilibrium (LD) with rs1796391. Co-localization of the signals is supported by the clustering of dots at top right. (Top right) –log10(p-value) from the Levene’s test on the y-axis and genomic coordinate on the x-axis. (Bottom right) -log₁₀(p-value) from the G × G interaction test between rs10511683 (FOCAD) and SNPs at the PRICKLE1 locus on the y-axis.