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. 2021 Aug 9;12:674642. doi: 10.3389/fgene.2021.674642

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Copyright © 2021 Liu, Ban, El Sergani, Lee, Hecht, Wehby, Moreno, Feingold, Marazita, Cha, Szabo-Rogers, Weinberg and Shaffer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prickle1 and Focadhesin proteins co-localize in the mouse cranial base mesenchyme. Dual immunofluorescence images of Prickle1 (green) and Focadhesin (red) proteins, with the nuclei stained with DAPI (blue). The areas within the white boxes are presented as single channels beside the combined image. (A,C) Embryonic day 12.5 cranial bases: in the Prickle1⁺^/⁺ mesenchyme, the Prickle1 and Focadhesin proteins are co-localized (yellow, arrows), while in the Prickle1^Bj/Bj mesenchyme, the signals are co-localized in bright foci, but in the cell periphery. (B,D) In Prickle1⁺^/⁺ chondrocytes, the signals co-localize (yellow, arrows) at the cleavage furrow. In Prickle1^Bj/Bj chondrocytes, Focadhesin is found in numerous puncta and in some cleavage furrows.