Scheme 1.

Schematic of the synthesis of curcumin-loaded nanoscale coordination polymers (Cur@NCPs) and their disassembly and release of curcumin, which induces the apoptosis of breast cancer cells (MDA-MB-231). The diblock copolymer PMPC-b-PserA self-assembles into NCP nanoparticles via complexation of Fe³⁺ and PserA. Cur@NCPs are produced by partitioning of curcumin into the hydrophobic particle core via oil-in-water emulsion. Addition of the chelating agent deferoxamine mesylate (DFO) in an acidic solution causes disassembly of the Cur@NCPs, curcumin release, and cell apoptosis.