Table 3. Main clinical and metabolic features pre- and post-treatment with GLP-1RA in IGT and IR-NG women.
| Variable | Post-treatment | Post-treatment | |
|---|---|---|---|
| Baseline | 3 months | 6 months | |
| BMI (kg/m2) | 28.43 ± 3.13 | 26.44 ± 2.97* | 25.91 ± 3.38** |
| Fat (%) | 39.99 ± 5.54 | 36.25 ± 4.12* | 35.88 ± 5.02** |
| WC (cm) | 88.86 ± 7.25 | 85.98 ± 7.10 | 84.56 ± 7.60* |
| SBP (mmHg) | 116.72 ± 11.72 | 111.32 ± 10.23 | 112.68 ± 12.33 |
| DBP (mmHg) | 74.08 ± 8.53 | 73.80 ± 10.08 | 73.24 ± 9.24 |
| TC (mmol/L) | 4.74 ± 0.74 | 4.26 ± 0.89* | 4.33 ± 0.82 |
| TG (mmol/L) | 1.89 ± 0.64 | 1.55 ± 0.67 | 1.41 ± 0.68* |
| HDL-C (mmol/L) | 1.14 ± 0.26 | 1.05 ± 0.18 | 1.08 ± 0.19 |
| LDL-C (mmol/L) | 3.00 ± 0.71 | 2.63 ± 0.82 | 2.62 ± 0.80 |
| FFAs (µmol/L) | 0.50 ± 0.17 | 0.44 ± 0.12 | 0.45 ± 0.22 |
| HbA1c (%) | 5.50 ± 0.36 | 5.26 ± 0.26** | 5.20 ± 0.24** |
| FBG (mmol/L) | 5.37 (5.14–5.47) | 5.17 (5.03–5.46) | 5.14 (4.93–5.24)* |
| 0.5h-BG (mmol/L) | 9.28(8.60–10.23) | 8.66 (7.58–10.15) | 8.59 (7.67–9.42)* |
| 1h-BG (mmol/L) | 9.14(7.62–10.48) | 8.46 (6.74–9.85) | 8.38 (7.49–9.79) |
| 2h-BG (mmol/L) | 7.81(6.82–8.83) | 6.84 (5.59–7.97) | 6.71 (5.73–8.29)* |
| FIns (mU/L) | 21.69 (16.00–31.07) | 17.66 (11.43-24.13)* | 13.42 (9.71 -22.59)** |
| 0.5h-Ins (mU/L) | 172.95 (126.80–210.10) | 145.70 (93.27–240.38) | 142.05 (91.20-209.55) |
| 1h-Ins (mU/L) | 173.70 (119.30–334.10) | 179.35 (108.73–261.58) | 185.20 (121.95-257.08) |
| 2h-Ins (mU/L) | 174.70 (119.95–269.58) | 154.25 (78.09–252.93) | 121.05 (78.76-194.08) |
| AUCi | 285.3 (224.3–556.5) | 304.3 (176.4–466.0) | 290.8 (192.6-399.5) |
| AUCg | 16.9 (14.9–18.3) | 15.5 (13.0–17.3) | 15.0 (13.9-17.4) |
| HOMA2-IR | 0.83 (0.78–0.85) | 0.78 (0.76–0.85) | 0.77 (0.73-0.80)* |
| M-value | 3.76 ± 0.73 | 5.11 ± 1.70** | 5.27 ± 1.79** |
| Fetuin-B (mg/L) | 8.08 ± 1.77 | 7.47 ± 1.48 | 6.75 ± 1.57* |
Notes.
Values were given as mean ± SD or median (interquartile range).
*
p < 0.05.
**
p < 0.01 vs. Baseline.
Δ
p < 0.05.
▴
p < 0.01 vs. post-treatment 3 months.