Figure 2.
Cache Valley Virus (CVV) infection results in significant morbidity and mortality in 3-week-old IFN-αβR-/- mice. Three-week-old mice (n = 9/group) were challenged subcutaneously with 104 plaque forming units (PFU) of virus and (a) survival and (b) weight change measured daily for 10 days post infection (DPI). (c) Viremia was measured on 1–4 d post infection, and (d) organ titers measured for spleen, kidney, brain, liver, ovary, heart and lung harvested 3 DPI. Each data point plotted represents the mean values and error bars indicate standard deviation. The limit of detection (LOD) is indicated with a dotted line. Statistical significance among groups were analysed by log-rank (Mantel-Cox) test in (a), and a mixed effects analysis with a Dunnett's multiple comparison test in (b–d). Statistically significant values are denoted by * (p < 0.05).