Figure 3.
Cache Valley Virus (CVV) infection results in significant viremia, morbidity, and mortality in 1-year-old IFN-αβR-/- mice. One-year-old mice (CVV 4B n = 12, CVV W08491 n = 12, PBS n = 8) were challenged subcutaneously with 104 plaque forming units (PFU) of virus and (a) weight change was measured daily for 6 days post infection (DPI). (b) Viremia was measured on 2–6 DPI, and organ titers for spleen, kidney, brain, liver, ovary, heart and lung at (c) 2 DPI, (d) 4 DPI, and (e) 6 DPI. Each data point plotted represents mean values, and error bars indicate standard deviation. The limit of detection (LOD) is indicated with a dotted line. Statistical significance among groups were analysed by a mixed effects analysis with a Dunnett's multiple comparison test in (a-e). Statistically significant values are denoted by * (p < 0.05).