Table 3.

The main pharmacokinetic parameters of ambrisentan in rat plasma in two groups (n = 6).

Parameters	Group A	Group B
AUC(0–t) (μg/L·h)	41,308.92 ± 19,275.09	53,368.89 ± 7,683.32*
AUC(0–∞) (μg/L·h)	44,893.16 ± 22,304.94	53,861.05 ± 7,773.54*
t1/2z (h)	0.92 ± 0.42	0.55 ± 0.11
Tmax (h)	0.60 ± 0.55	0.22 ± 0.08
Vz/F (L/kg)	0.09 ± 0.06	0.04 ± 0.01
CLz/F (L/h/kg)	0.07 ± 0.03	0.05 ± 0.01
Cmax (μg/L)	31,474.53 ± 18,255.05	57,182.51 ± 14,900.22*

Group A: control group; Group B: a single dose of 20 mg/kg shikonin. *p < 0.05.