Table 5.

Analysis of linear relationship of C_max, AUC_0–t, AUC_0–∞ with dose (dose range: 10–60 mg/kg)-calculated by actual dose.

Parameter	R2	α	β	P-value	90% CI of β (%)	Critical region
Ln(Cmax)	0.9640	−2.5435E-15	0.9819	<0.0001	0.9231–1.0406	0.8207–1.1798
Ln(AUC0–t)	0.9723	0.0277	1.0031	<0.0001	0.9475–1.0586	0.8879–1.1121
Ln(AUC0–∞)	0.9670	0.0276	1.0003	<0.0001	0.9398–1.0609	0.8879–1.1121