Table 3.
Comparison of clinical characteristics between pSS-NILD group and pSS-ILD group.
| Total (n = 563) | pSS-NILD (n = 323, 57.4%) | pSS-ILD (n = 240, 42.6%) | p | |
|---|---|---|---|---|
| Age at diagnosis (years) | 53 (16–83) | 50 (16–83) | 59 (23–83) | <.001 |
| Duration of disease (years) | 1.95 (0.8–3.2) | 1.95 (0.8–3.2) | 1.9 (0.9–2.8) | .912 |
| Male | 55 (9.8%) | 23 (7.1%) | 32 (13.3%) | .014 |
| Sicca symptoms | 357 (63.4%) | 202 (62.5%) | 155 (64.6%) | .618 |
| Rampant caries | 95 (16.9%) | 49 (15.2%) | 46 (19.2%) | .211 |
| Arthralgia | 168 (29.8%) | 95 (29.4%) | 73 (30.4%) | .797 |
| Purpura | 53 (9.4%) | 46 (14.2%) | 7 (2.9%) | <.001 |
| Raynaud's phenomenon | 61 (10.8%) | 20 (6.2%) | 41 (17.1%) | <.001 |
| Respiratory symptoms | 208 (36.9%) | 55 (17.0%) | 153 (63.8%) | <.001 |
| Digestive symptoms | 73 (13.0%) | 45 (13.9%) | 28 (11.7%) | .429 |
| Laboratory results | ||||
| Anti-SSA body | 429 (76.2%) | 249 (77.1%) | 180 (75.0%) | .565 |
| Anti-SSB body | 160 (28.4%) | 86 (26.6%) | 74 (30.8%) | .274 |
| Anti-Ro-52 body | 404 (71.8%) | 232 (71.8%) | 172 (71.7%) | .967 |
| Antinuclear antibodies | 387 (68.7%) | 217 (67.2%) | 170 (70.8%) | .355 |
| Rheumatoid factor | 87 (15.5%) | 52 (16.1%) | 35 (14.6%) | .623 |
| Proteinuriaa | 118 (21.0%) | 72 (22.3%) | 46 (19.2%) | .368 |
| Hypercreatinaemia, >133.0 µmol/L | 18 (3.2%) | 13 (4.0%) | 5 (2.1%) | .195 |
| Hyperglobulinaemia, >40.0 g/L | 104 (18.5%) | 53 (16.4%) | 51 (21.3%) | .143 |
| C3 (g/L) | 0.85 (0.17–3.15) | 0.85 (0.17–3.15) | 0.88 (0.22–1.7) | .085 |
| Albumin (g/L) | 35.7 (11.7–50.8) | 36.4 (11.7–50.1) | 34.8 (15.7–50.8) | .001 |
| Elevated ALT, >42 U/L | 18 (3.2%) | 8 (2.5%) | 10 (4.2%) | .260 |
| Elevated AST, >37 U/L | 14 (2.5%) | 6 (1.9%) | 8 (3.3%) | .266 |
| ESR (mm/h) | 37 (1–140) | 36 (2–140) | 39.5 (1–140) | .268 |
| CRP (mg/L) | 5.17 (0.08–251) | 4.73 (0.11–251) | 5.87 (0.08–165) | .153 |
| Haemoglobin (g/L) | 118 (18–200) | 118 (18–173) | 118 (60–200) | .767 |
| Leukocytes (×109/L) | 6.13 (0.41–20.59) | 6.06 (0.41–20.59) | 6.43 (1.93–20.01) | .384 |
| Lymphocytes (×109/L) | 1.41 (0.15–5.76) | 1.37 (0.15–5.76) | 1.47 (0.33–4.32) | .272 |
| Platelets (×109/L) | 186 (1–631) | 179 (1–631) | 196 (3–526) | <.001 |
pSS-NILD: primary Sjögren’s syndrome patients without interstitial lung disease; pSS-ILD: primary Sjögren’s syndrome patients with interstitial lung disease; C3: complements 3; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein.
Values are presented as number (%) or median (range).
a
The proteinuria is defined as the amount of protein in the urine beyond 150 mg/24 h.