Table 3.

Multivariable weighted Cox proportion hazard regression model for PPI

Factor	HR (95% CI)
Proton pump inhibitor use
Crude a	2.4 (1.4–4.0)
Proton pump inhibitor use adjusted for
Model 1: age	2.3 (1.4–4.0)
Model 2: sex	2.4 (1.3–4.3)
Model 3: BMI	1.9 (1.1–3.3)
Model 4: acetylsalicylic acid use	2.3 (1.2–4.3)
Model 5: vitamin K antagonist use	2.2 (1.0–5.0)
Model 6: immunosuppressive drug use	2.4 (1.1–5.4)
Model 7: polypharmacy.b	2.2 (1.1–4.1)
Model 8: all above	1.9 (0.4–10)

^a Crude = HR from univariable model (Table 2).

^b Defined as the daily use of ≥ 5 different medications.