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(A) In unstimulated, control conditions, leptin receptor is not active. (B) Upon leptin addition, leptin receptors are activated, and this activates downstream signaling molecules. In an hour after activation of leptin receptor, more β-PIX gets recruited to leptin receptors. (C) Later, more GABAA receptors are stabilized on the plasma membrane in the presence of β-PIX and gephyrin scaffolding.
