Table 3.
Adverse events with neoadjuvant chemotherapy
| Event | Grade 1–2 No. (%) |
Grade 3–4 No. (%) |
|---|---|---|
| Hematologic | ||
| Anemia | 62 (48.8%) | 7 (5.5%) |
| Neutropenia | 17 (13.4%) | 13 (10.2%) |
| Gastrointestinal | ||
| Nausea | 41 (32.3%) | 5 (3.9%) |
| Mucositis | 35 (27.6%) | 5 (3.9%) |
| Constipation | 12 (9.4%) | 0 |
| Dysgeusia | 6 (4.7%) | 0 |
| Diarrhea | 5 (3.9%) | 1 (0.8%) |
| Vomiting | 4 (3.1%) | 0 |
| Anorexia | 2 (1.6%) | 1 (0.8%) |
| Hepatitis | 1 (0.8%) | 1 (0.8%) |
| Neurotoxicity | 25 (19.7%) | 2 (1.6%) |
| Cutaneous | ||
| Alopecia | 127 (100%) | NA |
| Onycholysis | 12 (9.4%) | 3 (2.4%) |
| Hand-foot syndrome | 5 (3.9%) | 1 (0.8%) |
| Rash | 4 (3.1%) | 2 (1.6%) |
| Fatigue | 16 (12.6%) | 1 (0.8%) |
| Myalgias | 11 (8.7%) | 0 |
| Ocular | ||
| Watering eyes | 3 (2.4%) | 0 |
| Dry eye | 2 (1.6%) | 0 |
| Pyrexia | 1 (0.8%) | 0 |
| Hypersensitivity reaction | 1 (0.8%) | 2 (1.6%) |
No. — number; NA — not applicable