Table 2.
Parasitological and serological findings from congenital Chagas disease-infected infants during the follow-up
| Patient ID | Appointment | Age | Reference standard (ME or serology)a | Index tests | ||
|---|---|---|---|---|---|---|
| LAMP | qPCR | QPCR (par. eq./mL) | ||||
| 015 | T1 | 6 D | Pos | Pos | Pos | 706.2 |
| 032 | T1 | 5 D | Pos | Pos | Pos | 23.6 |
| 037 | T1 | 9 D | Pos | Pos | Pos | 347.8 |
| 042 | T1 | 7.1 M | Pos | Pos | Pos | 4718.3 |
| 052 | T1 | 39 D | Neg | Neg | Pos | NQ |
| T2 | 10.5 M | Neg | ND | Pos | 73.6 | |
| T2bis | 19.2 M | Pos | ND | Pos | 7.8 | |
| 053 | T1 | 8 D | Neg | ND | ND | ND |
| T2 | 10.6 M | Pos | Pos | Pos | 2145.3 | |
| 061 | T1 | 17 D | Neg | Neg | Pos | NQ |
| T2 | 9.1 M | Pos | ND | Pos | 543.1 | |
| 084 | T1 | 53 D | Pos | Pos | Pos | 257.8 |
| 091 | T1 | 4 D | Pos | Pos | Pos | 2058.3 |
| 101 | T1 | 11 D | Neg | Neg | Pos | 27.5 |
| T1bis | 3.7 M | Pos | Pos | Pos | 3392.8 | |
| 118 | T1 | 29 D | Pos | Pos | Pos | 164.7 |
| 140 | T1 | 84 D | Pos | Pos | Pos | 1698.0 |
| 141 | T1 | 44 D | Pos | Neg | Pos | 320.0 |
D days, LAMP isothermal assay, M months, ME microscopic examination, ND not done, Neg no detectable parasites or non-reactive serology as appropriate, NQ not quantifiable (<0.5 par. eq./mL), par. eq./mL parasite equivalents per milliliter of blood, Pos detectable or reactive as appropriate, qPCR real-time PCR, QPCR quantitative PCR, T1 baseline, T2 after 9 months of age, T1bis and T2bis off-label appointments
aReference standard, ME at baseline (T1 and T1bis) and serology at 9 months old or more if ME was negative (T2 and T2bis)