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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Curr Opin Electrochem. 2021 Jun 7;30:100780. doi: 10.1016/j.coelec.2021.100780

Figure 1.

Figure 1.

(a) The active site of fungal laccase from Trametes hirsuta (PDB:3fpx) showing the electron transfer from the T1Cu center to the site of O2 reduction at the trinuclear copper center in MCOs. (b) The T1Cu center of the fungal laccase from T. hirsuta. (c) The hydrophobic Phe residues in the SCS of fungal laccase are shown in tan and the T1Cu center is highlighted in green. (d) Sequence alignment of MCOs showing the PCS in green of the T1Cu center and the analogous sites for hydrogen bonding to the S(Cys) residue shown in red. MCOs have a conserved Pro residue in the analogous azurin Asn47 position indicating one hydrogen bond to the S(Cys) rather than two.