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. 2021 Aug;100(2):66–81. doi: 10.1124/molpharm.120.000226

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Fig. 6. — Escitalopram increases potency of isoproterenol-stimulated whole-cell cAMP. Three days of treatment with 10 μM escitalopram increases the potency of isoproterenol-stimulated cAMP production but has no effect on maximal accumulation in C6 cells expressing the cytoplasmic cAMP sensor (A). This is reversed 24 hours after escitalopram withdrawal (B). r-Citalopram has no effect on isoproterenol-stimulated cytoplasmic cAMP in C6 cells (C and D). ^#P < 0.05, compared with top end of vehicle control curve. n = 4.