Table 15:

Cost of Treatment-Related Toxicities

Model Parameter	Mean Cost, $	SE	Distribution	Reference
Hospital cost per day (for patients with severe toxicities requiring hospitalization)	1,232.10a	246.42	Gamma	CIHI 201696
Non-hospitalization cost for non-severe toxicities (Grade 0–2)c	144.90b	28.98	Gamma	Henricks et al, 201980
Non-hospitalization cost for severe toxicities that did not require hospitalization (grade ≥ 3)c	394.26d	78.85	Gamma

Abbreviations: CIHI, Canadian Institute for Health Information; SE, standard error.

^aInflated from 2015 to 2020 CAD.

^bCost per event = €82, converted using purchasing power parity.⁹⁷

^cGrade score based on the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) ratings system for level of toxicity.

^dCost per event = €234, converted using purchasing power parity.⁹⁷