Table 16:

Drug Acquisition Costs per 21-Day Cycle, Standard Dosing

Drug	Dosing		Drug Costs			Reference
	Starting Dose	Dose per Day or Cyclea	Cost per mg	Cost per Day	Cost per Cycle
Capecitabine	Low: 825 mg/m2 2× daily for 14 d High: 1,250 mg/m2 2× daily for 14 d	3,135 mg/d 4,750 mg/d	$1.5250 per pill (500 mg); $0.4575 per pill (150 mg)	$10.38b $16.47b	$145.32b $230.58b Average: $187.95b	Henricks et al, 201881; OH (CCO); ODB Formulary98
5-FU	Low: IV bolus, 500–600 mg/m2 on days 1 and 8 High: IV infusion, 200 mg/m2 on days 1–21	2,090 mg/cycle 7,980 mg/cycle	$0.003 per mg	— —	$6.27 $23.94 Average: $15.11	Henricks et al, 201881; OH (CCO); pCODR99
Raltitrexed	3 mg/m2 on day 1	5.7 mg/cycle	$324.62 per 2 mg	—	$925.17	Alberta Blue Cross103; OH (CCO)102,104

Abbreviations: 5-FU, f-fluorouracil; CADTH, Canadian Agency for Drugs and Technologies in Health; ODB, Ontario Drug Benefit program; OH (CCO), Ontario Health (Cancer Care Ontario); pCODR, pan-Canadian Oncology Drug Review.

^aCalculated assuming a mean body surface area of 1.9 m² (Lunenburg et al 2018⁷).

^bAn 8% markup was included for oral drugs (CADTH costing guidance document).