Table 4:
DPYD Genotyping to Detect Severe Toxicity (3–4 Variants)—Sensitivity, Specificity, PPV, and NPV
| Author, Year | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % | NPV, % |
|---|---|---|---|---|
| Lunenburg et al, 20187 | 7.1 (3.6–13.4) | 96.2 (94.6–97.4) | 23.5 | 86.4 |
| Meulendijks et al, 201718 | 6.0 (NR)a | 95.0 (NR)a | 13.0a | 88.0a |
| Boige et al, 201615 | 3.5 (2.5–5.1) | 99.0 (98.0–99.5) | 77.8 | 50.5 |
| Froehlich et al, 201557 | 21.6 (12.5–34.6) | 95.3 (93.0–96.9) | 34.4 | 91.5 |
| Toffoli et al, 20159 | 11.6 (0.7–19.6) | 98.6 (97.2–99.3) | 61.1 | 85.6 |
| Lee et al, 201458 | 5.3 (4.0–7.0) | 99.4 (98.9–99.7) | 82.5 | 67.4 |
| Jennings et al, 201359 | 15.9 (7.9–29.4) | 96.2 (92.6–98.0) | 46.7 | 84.5 |
| Loganayagam et al, 201360 | 9.6 (5.3–16.8) | 100.0 (98.8–100.0) | 100.0 | 77.6 |
| Cellier et al, 201162 | 8.1 (2.8–21.3) | 100.0 (92.6–100.0) | 100.0 | 58.5 |
Abbreviations: CI, confidence interval; NPV, negative predictive value; NR, not reported; PPV, positive predictive value.
a
As reported by the authors.