Table 5:
DPYD Carriers Versus Wild-Type Patients—Toxicity-Related Hospitalization
| Author, Year N (Carrier/Wild-Type) DPYD Variants Included | Patients With Toxicity-Related Hospitalization, n (%) | RR (95% CI) | Number of Days in Hospital, Mean (Range) |
|---|---|---|---|
| Lunenburg et al, 20187 805 (34/771) DPYD∗2A, DPYD∗13, c.2846A>T, c.1236G>A |
Carrier: 6 (17.6) Wild-type: 60 (7.8) |
2.26 (0.69—5.14) | Carrier: 23 (6–36) Wild-type: 13 (1–76) |
| Loganayagam et al, 201360 430 (10/420) DPYD∗2A, DPYD∗13, c.2846A>T |
Carrier: 10 (100.0) Wild-type: 94 (22.4) |
4.46 (3.26–5.29) | Carrier: 7.1 Wild-type: 2.7 |
| Boisdron-Celle et al, 200767 243 (1/242) Compound heterozygous (DPYD∗2A/c.2846A>T) |
Carrier: 1 (100.0) Wild-type: 4 (1.7) |
58.82 (15.19–168.60) | Carrier: 40 Wild-type: NR |
| Largillier et al, 200668 105 (1/104) DPYD∗2A |
Carrier: 1 (100) Wild-type: NR |
Could not be calculated | Carrier: 7 Wild-type: NR |
| Salgueiro et al, 200469 73 (1/72) DPYD∗2A |
Carrier: 1 (100.0) Wild-type: NR |
Could not be calculated | NR |
Abbreviations: CI, confidence interval; NR, not reported; RR, risk ratio.