Table 6:
Heterozygous DPYD Carriers Versus Wild-Type Patients—Toxicity-Related Mortality
| Author, Year N (Carrier/Wild-Type) | Mortality (Any DPYD Variant, Heterozygous), n (%); Time of Occurrence |
|---|---|
| Wigle et al, 202171 1,388 (41/1,347) |
Carrier: 0 Wild-type: 10 (0.7); timing unclear |
| Cremolini et al, 201855 438 (5/433) |
Carrier: 1 (10.0); cycle 1 Wild-type: NR |
| Etienne-Grimaldi et al, 201756 243 (6/237) |
Carrier: 1 (16.7); cycle 1 Wild-type: 0 |
| Loganayagam et al, 201360 430 (10/420) |
Carrier: 0 Wild-type: NR |
| Deenen et al, 201161 604 (44/560) |
Carrier: 1 (2.3); cycle 3 Wild-type: NR |
| Cerić et al, 201063 50 (1/49) |
Carrier: 1 (100.0); cycle 1 Wild-type: 1 (2.0); timing unclear |
| Schwab et al, 200865 683 (13/670) |
Carrier: 0 Wild-type: 0 |
| Boisdron-Celle et al, 200767 252 (10/242) |
Carrier: 0 Wild-type: 1 (0.4); timing unclear |
| Largillier et al, 200668 105 (1/104) |
Carrier: 1 (100.0); treated until day 12 Wild-type: 2 (1.9); timing unclear |
Abbreviation: NR, not reported.