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. 2021 Aug 12;21(13):1–214.

Table 24:

Budget Impact Analysis of Reference Case Results for Multi-gene Pharmacogenomic Testing in Ontario

  Budget Impact, $ Milliona
Year 1 Year 2 Year 3 Year 4 Year 5 Totalb,c
Current Scenario
Total costs $1,624.20 $1,650.44 $1,674.79 $1,697.16 $1,717.64 $8,364.22
Cost of testing 0.00 0.00 0.00 0.00 0.00 0.00
Medication cost 248.29 252.30 256.02 259.44 262.57 1,278.63
Other direct costsd 1,375.91 1,398.14 1,418.76 1,437.71 1,455.07 7,085.59
Future Scenario
Total costs $1,627.70 $1,657.47 $1,685.29 $1,710.93 $1,734.39 $8,415.77
Cost of testing 4.84 9.73 14.52 19.05 23.17 71.31
Medication cost 248.18 252.08 255.70 259.01 262.05 1,277.02
Other direct costsd 1,374.68 1,395.66 1,415.07 1,432.86 1,449.17 7,067.44
BI
Total BI 3.50 7.04 10.50 13.77 16.75 51.55
BI: Cost of testing 4.84 9.73 14.52 19.05 23.17 71.31
BI: Medication costb –0.11 –0.22 –0.33 –0.43 –0.52 –1.61
BI: Other direct costsd –1.23 –2.48 –3.70 –4.85 –5.90 –18.15

Abbreviation: BI, budget impact.

a

In 2020 Canadian dollars.

b

Negative costs indicate savings.

c

Results might appear incorrect due to rounding. The primary goal of our BIA was to estimate cost difference between two scenarios. Estimates of total costs for current and new scenarios are limited by data sources and methods used for this analysis, and they do not necessarily represent actual total costs of care.

d

Other direct medical costs include costs for physicians and health care services, excluding costs of medication.