Table A10:
GRADE Evidence Profile for Comparison of Treatment Guided by Unspecified Pharmacogenomic Test With Treatment as Usual—Change in Depression Score
| No. of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| 17-Item Hamilton Depression Rating Scale | |||||||
| 1 (RCT) | Very serious limitations (−;2)a | Noneb | No serious limitations | Serious limitations (−;1)c,d | Undetected | None | ⊕ Very Low |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development, and Evaluation; RCT, randomized controlled trial.
a
See Risk of Bias Table A5.
b
Not evaluable owing to single study.
c
No measures of variance for adjusted analyses were reported, and therefore imprecision could not be appropriately assessed. Based on reported data, point estimates did not meet clinically meaningful threshold of a 2- to 3-point difference in mean scores from Hamilton Depression Rating Scale.
d
Study sample sizes were small and unlikely to meet optimal information size.