Table A15:
GRADE Evidence Profile for Comparison of Unspecified Pharmacogenomic-Guided Treatment Selection and Treatment as Usual—Response
| No. of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| Response Based on 17-Item Hamilton Depression Rating Scale | |||||||
| 1 (RCT) | Serious limitations (−;1)a | No serious limitations | No serious limitations | Serious limitations (−;1)b | Undetected | None | ⊕⊕ Low |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development, and Evaluation; HAM-D17, 17-item Hamilton Depression Rating Scale; RCT, randomized controlled trial.
a
See Risk of Bias Table A5.
b
Study had very small sample size and was unlikely to meet optimal information size. Confidence intervals span both large benefit and potential harm.