Table A2:
Scales and Scoring Used by Included Primary Studies
| Scale | Description | Number of Items and Scoring |
|---|---|---|
| HAM-D17152 | 17-item rating scale pertaining to symptoms of depression experienced over the past week | Total score ranging from 0–52; higher scores reflect greater severity of depression |
| HAM-D6153 | 6-item subscale of HAM-D17 (see above) | Total score ranging from 0–22; higher scores reflect greater severity of depression |
| SIGH-D17154 | Standardized manner of administration and scoring of the HAM-D17 scale (see above) | Total score ranging from 0–52; higher scores reflect greater severity of depression |
| QIDS-C16 or QIDS-SR16155 | 16 item scale pertaining to symptoms of depression over the last seven days | Total score ranging from 0–27; higher scores reflecting greater severity of depression |
| PHQ-9156 | 9-item scale pertaining to symptoms of depression over the last 2 weeks | Total score ranging from 0–27; higher scores reflect greater severity of depression |
| CGI-S and CGI-I157 | A two-component scale applicable to all psychiatric disorders, rated by the clinician: CGI-S rates illness severity as a single clinician question and CGI-I compares the patient's overall clinical condition to the week before medication initiation | Each question is scored from 1–7, ranging from 1 (normal) to 7 (among the most extremely ill patient) for CGI-S and 1 (very much improved since initiation of treatment) to 7 (very much worse since initiation of treatment) for CGI-I |
| FIBSER71 | A 3-question scale to assess patient side effects over the last week believed to be caused by depression medications. Three questions each correspond to the subscales of Frequency, Intensity, and Burden | Each question is rated from 0–6, ranging from 0 (least severe) to 6 (most severe). Clinical relevance is rated for each question: 0–2 indicates no changes needed, 3–4 suggests side effects should be addressed, and 5–6 indicates change in treatment |
Abbreviations: CGI-I, Clinical Global Impressions Scale I (improvement) or S (severity of illness); FIBSER, Frequency, Intensity and Burden of Side Effects; HAM-D6, 6-item Hamilton Depression Rating Scale; HAM-D17, 17-item Hamilton Depression Rating Scale; PHQ-9, 9-Item Patient Health Questionnaire; QIDS-C16, 16-Item Quick Inventory of Depressive Symptomatology (clinician-rated); QIDS-SR16, 16-Item Quick Inventory of Depressive Symptomatology (patient self-report); SIGH-D17, Structured Interview Guide for the HAM-D17.