Table A21:
GRADE Evidence Profile for Comparison of Unspecified Pharmacogenomic-Guided Treatment Selection and Treatment as Usual—Remission
| No. of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| Response Based on Hamilton Depression Rating Scale | |||||||
| 1 (RCT) | Very serious limitations (−;2)a | No serious limitations | No serious limitations | Serious limitations (−;1)b | Undetected | None | ⊕ Very Low |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development, and Evaluation; RCT, randomized controlled trial.
a
See Risk of Bias Table A5.
b
Effect estimate spans both large benefit and small harm. Sample size was small and unlikely to meet optimal information size.