Table A25:
Change in HAM-D17 Scores—Sub-population Analyses
| Author, Year (Primary Study) | Subgroup (N PGx/TAU) | Mean Changea From Baseline to Follow-Up (SD) | P Value | |
|---|---|---|---|---|
| PGx | TAU | |||
| Severity of Depression at Baseline | ||||
| Menchon et al, 201969 (Perez et al62) | HAM-D17 < 18 (61/61)b HAM-D17 ≥ 18 (91/96)b HAM-D17 ≥ 25 (37/23)b |
–4.5 (5.4) 10.5 (8.2) –13.0 (8.8) |
–4.8 (5.7) –7.6 (7.8) –10.2 (8.0) |
.742 .020 .250 |
| Prior Depression Medication Use | ||||
| Perez et al, 201762 | 1–3 failed (90/83)b 0 failed (21/23)b 1 failed (27/28)b 2 failed (32/27)b 3 failed (31/28)b 4+ failed (30/33)b |
–8.86 (7.37) –7.67 (8.68) –9.19 (7.28) –8.88 (7.92) –8.55 (7.09) –5.87 (7.86) |
–5.86 (7.4) –7.57 (6.96) –5.79 (6.95) –5.93 (7.69) –5.86 (7.82) –7.24 (6.51) |
.0083 NS NS NS NS NS |
| Time Since Diagnosis | ||||
| Menchon et al, 201969 (Perez et al, 201762) | ≤ 1 y (79/73)b ≤ 5 y (113/111)b >5 y (42/50)b |
–9.5 (8.7) –8.8 (8.0) –6.0 (6.6) |
–6.6 (7.3) –6.2 (7.7) –7.0 (5.8) |
.035 .022 .518 |
| Age | ||||
| Forester et al, 202067 (Greden et al, 201957) | Age ≥ 65 (86/98) | % Δ 26.7 (3.6) | % Δ 18.7 (3.4) | .102 |
| Menchon et al, 201969 (Perez et al, 201762) | Age < 60 (111/122)b Age ≥ 60 (44/39)b |
–8.0 (7.8) –8.0 (7.5) |
–5.6 (7.2) –9.1 (6.4) |
.02 .522 |
Abbreviations: Δ, change from baseline; HAM-D17, 17-item Hamilton Depression Rating Scale; MD, mean difference; NR, not reported; NS, not significant; PR, patient-rated; SD, standard deviation.
a
Mean difference at follow-up, unless change from baseline data (Δ) reported by original article.
b
Number of participants at baseline; unclear which values used in follow-up data calculation. and therefore mean differences and confidence intervals were not calculated.