Table A3:
Primary Study Baseline Characteristics
| Author, Year Test | Mean Age (SD), y | Sex (% F) | Race/Ethnicity (%) | Psychiatric Comorbidities | Baseline HAM-D17 (SD) | Mean No. Previous Medication Trials (SD) | Baseline PGx Drug Category | |
|---|---|---|---|---|---|---|---|---|
| PGx | TAU | |||||||
| Greden et al, 2019a GeneSight |
PGx: 47.3 (14.6) TAU: 48 (14.4) |
PGx: 71.6 TAU: 68.5 |
White 80 Black 16.1 Asian 1.7 American Indian or Alaska Native 0.7 Native Hawaiian or Pacific Islander 0.1 Other/multi 1.4 |
White 82.6 Black 12.7 Asian 2.4 American Indian or Alaska Native 0.4 Native Hawaiian or Pacific Islander 0.1 Other/multi 1.8 |
PP cohort overall GAD 15.2 Panic or social phobia 15.2 PTSD 4.9 |
PGx: 20.5 (4.8) TAU: 20.7 (4.9) |
PGx: 3.4 (3.0) TAU: 3.5 (3.0) |
PP cohort cverall Use as directed 25.5% Use with caution 41.1% Use with increased caution 18.3% Not on report 15.0% |
| Winner et al, 201365 GeneSight |
PGx: 50.6 (14.6) TAU: 47.8 (13.9) |
PGx: 69 TAU: 92e |
Non-Hispanic White 96 African American 4 |
Non-Hispanic White 100 | NR | NR | PGx: 4.3 TAU: 4.5 |
NR |
| Hall-Flavin et al, 201355 GeneSight |
PGx: 41 (12.8) TAU: 44 (12.1) |
PGx: 69 TAU: 77 |
NR: almost exclusively identified as European ancestry | NR | PGx: 23 (5.1) TAU: 22.5 (5.4) |
PGx: 3.6 (3.5) TAU: 4.7 (3.5)e |
NR for all baseline categories Medication not on PGx report: TAU (16.6%), PGx (11.6%) |
|
| Hall-Flavin et al, 201256 GeneSight |
PGx: 42.1 (13.6) TAU: 42.6 (13.1) |
PGx: 54.5 TAU: 54.5 |
NR: almost exclusively identified as European ancestry | NR | NR | PGx: 1.7 (0.8) TAU: 2.2 (1.4) |
NR | |
| Bradley et al, 201858,b NeuroID-genetix |
PGxb: 47.8 (14.5) TAUb: 47.3 (15.2) |
PGxb: 73 TAUb: 72 |
Caucasianb 63 African Americanb 18 Hispanicb 16 Asianb 1 Otherb 2 |
Caucasianb 63 African Americanb 18 Hispanicb 17 Asianb 1 Otherb 1 |
PGX: depression + anxiety 43.9c TAU: depression + anxiety: 46.9c |
PGx: 20 (5.8)c TAU: 20 (5.6)c |
NR | NR |
| Han et al, 201860 Neuro-pharmagen |
PGx: 44.2 (16.1) TAU: 43.9 (13.8) |
PGx: 76.9 TAU: 72.9 |
Korean 100 | Korean 100 | NR | PGx: 24.5 (4.6) TAU: 23.1 (5.0) |
PGx: 2.5 (2.2) TAU: 2.1 (1.5) |
NR |
| Perez et al, 201762 Neuro-pharmagen |
PGx: 51.74 (12.0) TAU: 50.74 (13.1) |
PGx: 63.9 TAU: 63.4 |
Caucasian 93.5 Latin American 4.5 Other 2.0 |
Caucasian 91.3 Latin American 6.2 Other 2.5 |
Overall Anxiety 35.8 Substance abuse 12.6 |
PGx: 19.5 (6.0) TAU: 19.0 (5.7) |
PGx: 2.5 (2.3) TAU: 2.6 (2.1) |
NR |
| Perlis et al, 202061 Genecept |
PGx: 47.8 (12.4) TAU: 47.6 (12.1) |
PGx: 70.9 TAU: 72.5 |
Asian 0 American Indian or Alaskan Native 1.3 Black or African American 21.9 Native Hawaiian or other Pacific Islander 0.7 White 73.5 Other 2.6 |
Asian 0.7 American Indian or Alaskan Native 0.7 Black or African American 24.8 Native Hawaiian or other Pacific Islander 1.3 White 71.9 Other 0.7 |
NR | PGx: 22.5 (3.4) TAU: 22.1 (3.2) |
PGx 0–0.7 1–70.2 2 or 3–29.1 TAU 1–66 2 or 3–33.3 > 3–0.7 |
NR |
| Shan et al, 201963 Not specified |
PGx: 26.5 (7.9) TAU: 28.8 (8.9) |
PGx: 63 TAU: 65 |
Han Chinese 100 | Han Chinese 100 | Excluded other diagnoses | PGx: 21.0 (3.8) TAU: 20.9 (5.7) |
NR | NR |
| Singh et al, 201564 CNSDose |
PGx: 44.2 TAU: 44.3 |
PGx: 58 TAU: 61 |
Caucasian 100 | Caucasian 100 | Excluded other active diagnoses | PGx: 24.8 TAU: 24.7 |
NR | NR |
Abbreviations: GAD, generalized anxiety disorder; HAM-D17, 17-item Hamilton Depression Rating Scale; NR, not reported; PGx, pharmacogenomic-guided treatment; PP, per protocol; PTSD, post-traumatic stress disorder; SD, standard deviation; TAU, treatment as usual.
Results reported for full cohort (intention to treat) unless not reported, as specified. No substantial differences in demographics or disease between per protocol and full cohorts.
Data for depression cohort (N = 450) not reported separately. Estimates reflect combined anxiety or depression cohort (N = 685) and are not specific to those with depression alone. Depression cohort data alone were included in results.
Percentage of patients among patients in depression cohort (N = 450).
Estimated from graph using WebPlotDigitizer.
Statistically significant difference between PGx and TAU.