Table A9:
GRADE Evidence Profile for the Comparison of Genecept-Guided Treatment Selection and Treatment as Usual—Change in Depression Score
| No. of Studies (Design) | Risk of Bias | Inconsistency | Indirectness | Imprecision | Publication Bias | Upgrade Considerations | Quality |
|---|---|---|---|---|---|---|---|
| 17-Item Hamilton Depression Rating Scale | |||||||
| 1 (RCT) | Serious limitations (−;1)a | Noneb | No serious limitations | Serious limitations (−;1)c | Undetected | None | ⊕⊕ Low |
| 16-Item Quick Inventory of Depressive Symptomatology | |||||||
| 1 (RCTs) | Serious limitations (−;1)a | Noneb | No serious limitations | Serious limitations (−;1)d | Undetected | None | ⊕⊕ Low |
| Clinical Global Impression Scale–Severity | |||||||
| 1 (RCTs) | Serious limitations (−;1)a | Noneb | No serious limitations | Serious limitations (−;1)d | Undetected | None | ⊕⊕ Low |
Abbreviations: GRADE, Grading of Recommendations Assessment, Development, and Evaluation; RCT, randomized controlled trial.
a
See Risk of Bias Table A5.
b
Not evaluable owing to single study.
c
Mean difference was not clinically meaningful and ranged from potential harm to small benefit.
d
Mean differences crossed both potential benefit and harm.