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. Author manuscript; available in PMC: 2021 Aug 23.
Published in final edited form as: Cell Rep. 2021 Aug 3;36(5):109495. doi: 10.1016/j.celrep.2021.109495

Figure 1. Elevated neuronal firing of striatal medium spiny neurons (MSNs) in adult NaV1.2-deficient mice.

Figure 1.

(A) A typical MSN labeled by neurobiotin. Scale bar, 40 μm.

(B) Representative current-clamp recordings of MSNs from wild-type (WT, black) and homozygous (HOM) Scn2agt/gt (blue) mice were obtained at the RMP. Inset: representative trace in response to +350 pA injection.

(C) The average number of action potentials (APs) generated in response to depolarizing current pulses. Unpaired two-tailed non-parametric Mann-Whitney U test for each current pulse.

(D) Individuals and mean RMP values. Unpaired t test.

(Ei) Representative traces in response to −100 pA injection. Vsteady-state (Vss) is the voltage recorded 0–10 ms before the end of the stimulus.

(Eii) Individuals and mean input resistance values at the RMP. Unpaired t test.

(F) Typical spikes of MSNs from WT (black) and HOM (blue) mice were obtained at the normal RMP.

(G) Associated phase-plane plots.

(H–L) Individual and mean spike rheobase, voltage threshold, amplitude, fast after-hyperpolarization (AHP), and half-width values. Unpaired t test. Data are shown as mean ± SEM.