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. 2020 Dec 26;15(3):412–419. doi: 10.1055/s-0040-1721234

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European Journal of Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 2 — Experimental timeline for the establishment of the rabbit relapse movement model. Rabbits were randomly divided into three groups: control (G1), CHA hydrogel injection (G2), and CHA hydrogel-aPRF injection (G3). Each group included 15 rabbits, and all rabbits received an orthodontic force of 50 cN for 7 days, following 14 days of retention period. Rabbits in G2 and G3 received CHA and CHA-aPRF injection every 7 days during the retention period. The period of orthodontic relapse began after appliance debonding for all groups. Three rabbits were sacrificed on five subsequent time points (0, 3, 7, 14, and 21 days after debonding) in each group. aPRF, autologous platelet-rich fibrin; CHA, carbonate apatite.