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. 2021 Jul 12;134(16):1897–1907. doi: 10.1097/CM9.0000000000001628

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Copyright © 2021 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

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The mechanism map to summarize the mechanism of ROS in leukemia. ROS plays an important role in the process of ER stress, mitochondrial dysfunction, inflammatory response, autophagy, etc. BCL-2: B-cell lymphoma protein-2; ER: Endoplasmic reticulum; GSH: Glutathione; JAK: Janus kinase; Keap: Kelch-like ECH-associated protein; MAPK: Mitogen-activated protein kinase; Nrf2: Nuclear factor, erythroid 2 like 2; ROS: Reactive oxygen species; SOD: Superoxide dismutase; STAT: Signal transducer and activator of transcription; UPR: Unfolded protein response.