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. 2021 Aug 12;8(5):e1041. doi: 10.1212/NXI.0000000000001041

Figure 2. Validation of the Differential Expression of the Selected circRNA in RRMS.

Figure 2

(A) The expression levels of the indicated circRNA were analyzed using qRT-PCR. Significance was determined by analysis of variance with the Scheffé post hoc test. *p < 0.05, **p < 0.01, and ***p < 0.0001. The bold line represents mean value (±SD). (B) ROCs for the comparison of hsa_circ_101348, hsa_circ_102611, and hsa_circ_104361 expression in (B.a) RRMS relapse vs controls, (B.b) RRMS remission vs controls, and (B.c) RRMS relapse versus remission. circRNA = circular RNA; ROC = receiver operating characteristic; RRMS = relapsing-remitting multiple sclerosis; qRT = quantitative reverse transcription.