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. 2021 Aug 12;8(5):e1041. doi: 10.1212/NXI.0000000000001041

Figure 3. circRNA Expression in PBMC is Increased in Relation to Magnetic Resonance Imaging Activity in RRMS.

Figure 3

(A) Box and whisker plots of relative expression of indicated circRNA in PBMCs in gadolinium-enhanced (Gd)+ (n = 11) and in (Gd)− (n =13) patients with RRMS. Significance was determined by the Student t test. *p < 0.05. PBMCs (B.a) hsa_circRNA_101348, (B.b) hsa_circRNA_102611, and (B.c) hsa_circRNA_104361 expression levels were plotted against disease duration. Circles represent individual data, and the line represents a correlation trend; p values were calculated by R2 statistic. PBMCs (C.a) hsa_circRNA_101348, (C.b) hsa_circRNA_102611, and (C.c) hsa_circRNA_104361 expression levels were plotted against EDSS. Circles represent individual data, and the line represents a correlation trend; p values were calculated by R2 statistics. circRNA = circular RNA; EDSS = expanded disability severity scale; PBMCs = peripheral blood mononuclear cells; RRMS = relapsing-remitting multiple sclerosis.