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. 2021 Aug 12;8(5):e1041. doi: 10.1212/NXI.0000000000001041

Figure 4. mRNA Predicted From miRNA Identified as Interacting With CircRNA.

Figure 4

(A) The Venn diagrams display the overlap of the mRNA predicted from the hsa_circRNA_101348–regulated miRNA (hsa-miR-141-5p, hsa-miR-382-3p, hsa-miR-601, hsa-miR-134-3p, and hsa-miR-642a-5p); hsa_circRNA_102611–regulated miRNA (hsa-miR-130b-3p, hsa-miR-130a-3p, hsa-miR-513a-3p, hsa-miR-136-5p, and hsa-miR-301a-3p), and hsa_circRNA_104361–regulated miRNA (hsa-miR-608, hsa-miR-320a, hsa-miR-320b, hsa-miR-320c, and hsa-miR-885-3p). The figures indicate the numbers of the overlapping mRNAs regulated by corresponding miRNAs. (B) The Venn diagram of the overlapping mRNA regulated by all miRNA predicted to interact with hsa_circRNA_101348, hsa_circRNA_102611, or hsa_circRNA_104361. Figures indicate the numbers of the overlapping mRNAs regulated by all miRNAs predicted from a single circRNA. (C) Validation of differential expression of mRNAs in PBMCs in relapsing-remitting multiple sclerosis. Expression levels of the indicated mRNAs were analyzed using qRT-PCR. Significance was determined by analysis of variance with the Scheffé post hoc test. Dashed line represents mean value (±SD). ****p < 10−16. circRNA = circular RNA; miRNA = microRNA; PBMCs = peripheral blood mononuclear cells; RRMS = relapsing-remitting multiple sclerosis; qRT = quantitative reverse transcription.