Table 1.

Integrating data on possible gene variability as factors determining the susceptibility to SARS-CoV-2 and the course of COVID-19.

Possible targets	Relevant bibliography
Virus entry and replication
ACE2	[11, 19, 20, 69, 70, 71, 72]
TMPRSS2	[11, 77, 78, 79, 80, 82]
Furin	[81]
Angiotensin I receptor	[60, 61, 62]
Cathepsins B and L	[21, 77, 85]
Protein kinase R	[23, 39, 40]
Protein kinase R endoplasmic reticulum kinase (PERK)	[51, 52]
	[23]
dsRNA sensor melanoma differentiation-associated protein 5, 2′-5′-oligoadenylate synthase 3	[23]
	[41]
	[28]
Elongation initiation factor 2α	[22, 83, 84]
CD11	[54]
CD147
Cyclophilins
Presentation and recognition of virus antigens
HLA class I and II molecules	[87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 99]
TCRs	[99, 100, 101, 102]
BCRs	[98]
Haemocoagulation
Vitronectin	[55]
Plasmonogen	[81]
Plasminogen activator inhibitor 1	[56]
Von Willebrand factor	[57]
Factors of complement	[65, 66, 67]
Methylenetetrahydrofolate reductase	[123, 124]
Factor XIII	[124]
Vitamin K epoxide reductase complex I	[122]
Apoptosis/cell cycle
FAS-associated death domain (FADD)/caspase-8/caspase-3, caspase-9 apoptotic protease-activating factor-1 (APAF-1)	[39, 40]
Oxidative stress/metabolism
Phospholipase A2G2D	[18, 59]
D-type prostanoid receptor	[58]
Various types of NADPH oxidase	[61, 62]
iNOS, COX-2	[46, 47]
Hemoxigenase-1 (HO-1)	[120, 121]
Glutation S-transferase	[117]
Interferon system
Interferon regulatory factor 1	[78, 79]
IFNα	[24]
IFNβ, IFNg	[103]
Proinflammatory cascades
IκB	[31]
NFκB	[31, 114]
p38 MAPK	[32]
Activating transcription factor 4	[36]
TLR3 – signaling pathway	[112, 114, 115]
TLR7 – signaling pathway	[113]
TLR4	[111]
Retinoic acid-inducible gene 1 signaling pathway	[26, 27]
NLRP3 (cryopyrin) pathway	[50]
IL-6	[116]
IL-1α/1β	[42, 43]
IL-2	[54]
TNF-α	[37]