Table 2.
Clinical characteristics of the participants included in the transcriptomic analysis
| Characteristic | NGT | Type 2 diabetes | p value |
|---|---|---|---|
| Age (years) | 58 ± 1.8 | 62 ± 1.3 | 0.0185 |
| Weight (kg) | 84 ± 1.7 | 89 ± 1.9 | 0.0314 |
| Height (m) | 1.80 ± 0.02 | 1.79 ± 0.01 | 0.7185 |
| BMI (kg/m2) | 25.98 ± 0.35 | 27.94 ± 0.48 | 0.0020 |
| Waist (cm) | 93 ± 1.4 | 101 ± 1.7 | 0.0020 |
| Hip (cm) | 99 ± 0.9 | 101 ± 1.3 | 0.1691 |
| WHR | 0.94 ± 0.01 | 0.99 ± 0.01 | 0.0009 |
| Pulse (beats/min) | 61 ± 1.4 | 68 ± 1.6 | 0.0072 |
| Fasting plasma glucose (mmol/l) | 5.46 ± 0.08 | 8.56 ± 0.39 | <0.0001 |
| 120 min plasma glucose (mmol/l) | 5.89 ± 0.27 | 16.20 ± 0.69 | <0.0001 |
| HbA1c (mmol/mol) | 35.76 ± 0.64 | 50.44 ± 1.50 | <0.0001 |
| HbA1c (%) | 5.4 ± 0.06 | 6.8 ± 0.14 | <0.0001 |
| Serum insulin (pmol/l) | 52.71 ± 5.58 | 92.58 ± 9.01 | 0.0008 |
| 120 min serum insulin (pmol/l) | 314.9 ± 50.8 | 350.5 ± 42.4 | 0.5937 |
| Plasma creatinine (μmol/l) | 83.64 ± 2.36 | 79.71 ± 2.29 | 0.2307 |
| Plasma AST (μkat/l) | 0.38 ± 0.03 | 0.40 ± 0.03 | 0.7613 |
| Plasma ALT (μkat/l) | 0.42 ± 0.05 | 0.50 ± 0.04 | 0.2565 |
| Plasma triacylglycerol (mmol/l) | 1.25 ± 0.15 | 1.43 ± 0.13 | 0.4415 |
| Plasma cholesterol (mmol/l) | 5.40 ± 0.20 | 4.48 ± 0.15 | 0.0005 |
| Plasma HDL (mmol/l) | 1.30 ± 0.05 | 1.19 ± 0.06 | 0.1709 |
| Plasma LDL (mmol/l) | 3.56 ± 0.17 | 2.63 ± 0.15 | 0.0002 |
| Serum C-peptide (nmol/l) | 0.69 ± 0.04 | 1.03 ± 0.08 | 0.0008 |
| HOMA-IR | 1.86 ± 0.21 | 5.23 ± 0.64 | <0.0001 |
Results are shown as mean ± SEM for individuals with NGT (n = 25) and type 2 diabetes (n = 25)
Statistical analysis was performed using Student’s t test
ALT, alanine aminotransferase; AST, aspartate aminotransferase