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. 2021 Jul 16;64(9):2052–2060. doi: 10.1007/s00125-021-05492-6

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© The Author(s) 2021

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Fig. 6 — GADA affinity analysis. In total, 43 serum samples positive for RBA-GADA, including 17 samples from the Action LADA study (blue; nine confirmed by ECL assay and eight not confirmed by ECL assay) and 26 samples from the DiYA study (red; 18 confirmed by ECL assay and eight not confirmed by ECL assay) were analysed using competitive RBA and incubation with different concentrations of native GAD65 protein. GADA not confirmed by ECL assay (dotted line), compared with GADA confirmed by ECL assay (solid line), required higher concentrations of GAD65 protein for 50% maximal inhibition. Results were expressed as per cent of signal not absorbed