Table 2.
Uni- and multivariable binary regression analyses of clinical and laboratory markers associated with F ≥ 3 on liver biopsy and adjusted for (A) PNPLA3 genotype, (B) TM6SF2 genotype, (C) HSD17B13 genotype and (D) “risk-allele” model (one point for each risk allele, e.g., PNPLA3 G-Allele, TM6SF2 T-Allele, HSD17B13 T-Allele; groups “no risk alleles” and “1 risk allele” have been subsumed into one group; to overcome potential effects of dilution by combining risk polymorphisms [PNPLA3,TM6SF2] with protective polymorphisms [HSD17B13], HSD17B13 T-Allele carriage was classified as the “risk allele” [rather than TA-Allele carriage as “protective”] for the combined “risk-allele” model)
| Univariable | Multivariable | |||||
|---|---|---|---|---|---|---|
| OR | 95%CI | p-value | aOR | 95%CI | p-value | |
| A | ||||||
| Age, per year | 1.06 | 1.04–1.08 | < 0.001 | 1.04 | 1.02–1.07 | < 0.001 |
| Sex, for being male | 1.69 | 1.06–2.69 | 0.028 | 1.48 | 0.88–2.47 | 0.134 |
| BMI, per unit | 0.95 | 0.93–0.97 | < 0.001 | 0.98 | 0.95–1.001 | 0.057 |
| Diabetes, yes vs. no | 3.91 | 2.42–6.31 | < 0.001 | 3.36 | 1.98–5.69 | < 0.001 |
| PNPLA3 genotype | ||||||
| C/C vs. C/G | 1.39 | 0.82–2.34 | 0.224 | 1.51 | 0.85–2.65 | 0.155 |
| G/G | 3.40 | 1.80–6.41 | < 0.001 | 3.48 | 1.73–6.96 | < 0.001 |
| B | ||||||
| Age, per year | – | – | – | 1.04 | 1.02–1.06 | < 0.001 |
| Sex, for being male | – | – | – | 1.43 | 0.86–2.38 | 0.167 |
| BMI, per unit | – | – | – | 0.97 | 0.95–0.99 | 0.025 |
| Diabetes, yes vs. no | – | – | – | 3.45 | 2.05–5.82 | < 0.001 |
| TM6SF2 genotype | ||||||
| C/C vs. T/– | 1.82 | 1.05–3.15 | 0.033 | 1.99 | 1.10–3.62 | 0.023 |
| C | ||||||
| Age, per year | – | – | – | 1.04 | 1.02–1.06 | 0.001 |
| Sex, for being male | – | – | – | 1.44 | 0.86–2.38 | 0.160 |
| BMI, per unit | – | – | – | 0.97 | 0.94–0.99 | 0.016 |
| Diabetes, yes vs. no | – | – | – | 3.35 | 2.00–5.64 | < 0.001 |
| HSD17B13 genotype | ||||||
| T/T vs. T/TA | 0.81 | 0.49–1.33 | 0.406 | 0.86 | 0.50–1.48 | 0.596 |
| TA/TA | 0.70 | 0.27–1.83 | 0.462 | 0.84 | 0.30–2.31 | 0.734 |
| D | ||||||
| Age, per year | – | – | – | 1.04 | 1.02–1.06 | < 0.001 |
| Sex, for being male | – | – | – | 1.46 | 0.87–2.45 | 0.150 |
| BMI, per unit | – | – | – | 0.98 | 0.95–1.001 | 0.060 |
| Diabetes, yes vs. no | – | – | – | 3.44 | 2.02–5.85 | < 0.001 |
| Risk Alleles (Number of) | ||||||
| 0–1 Alleles vs. 2 | 2.31 | 1.04–5.17 | 0.041 | 2.21 | 0.96–5.12 | 0.064 |
| 3 | 2.59 | 1.13–5.98 | 0.025 | 2.61 | 1.09–6.26 | 0.032 |
| 4 | 4.54 | 1.78–11.56 | 0.002 | 4.34 | 1.61–11.66 | 0.004 |
| 5 | 12.33 | 3.52–43.23 | < 0.001 | 11.57 | 2.91–46.07 | 0.001 |