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. 2021 May 27;476(10):3623–3633. doi: 10.1007/s11010-021-04186-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Circ_0020093 overexpression or miR-23b inhibition ameliorated IL-1β-induced chondrocyte apoptosis and ECM degradation. A, B The efficiency of circ_0020093 overexpression and miR-23b inhibition in IL-1β-treated chondrocytes was checked by qRT-PCR. C, D The effects of circ_0020093 overexpression or miR-23b inhibition on cell apoptosis were determined by flow cytometry assay. The effects of circ_0020093 overexpression or miR-23b inhibition on the expression of Aggrecan, COL2, MMP13, MMP3, and ADAMTS4 were assessed by E, F qRT-PCR and G, H Western blot. *P < 0.05