Table 3.
Number of CD4 and CD8 T-cell responders among IMID-TBI, TBI subjects, and active-TB patients, enrolled before and after TB treatment.
| Stimulation and type of T-cell response | Type of cytokines produced | TBI-IMID(14) | TBI(12) | Active-TB(13) | p* | ||||
|---|---|---|---|---|---|---|---|---|---|
| T0 N |
T1 N |
T0 N |
T1 N |
T0 N |
T1 N |
T0 | T1 | ||
| TB1 specific CD4 T cells | Any cytokines | 13 (93) |
12 (86) |
11 (92) |
10 (83) |
10 (77) |
10 (77) |
0.493 | 0.878 |
| IFN-γ | 12 (86) |
10 (71) |
9 (75) |
8 (67) |
9 (69) |
8 (61) |
0.641 | 0.913 | |
| TNF-α | 11 (78) |
11 (78) |
11 (92) |
8 (67) |
10 (77) |
9 (69) |
0.665 | 0.822 | |
| IL-2 | 10 (71) |
11 (78) |
10 (83) |
8 (67) |
7 (54) |
7 (54) |
0.290 | 0.436 | |
| TB2 specific CD4 T cells | Any cytokines | 11 (78) |
12 (86) |
12 (100) |
11 (92) |
11 (85) |
11 (85) |
0.340 | 1.000 |
| CD4 IFN-γ | 11 (78) |
12 (86) |
10 (83) |
10 (83) |
10 (77) |
9 (69) |
1.000 | 0.610 | |
| TNF-α | 10 (71) |
12 (86) |
12 (100) |
9 (75) |
9 (69) |
9 (69) |
0.094 | 0.641 | |
| IL-2 | 9 (64) |
9 (64) |
10 (83) |
7 (58) |
6 (46) |
8 (61) |
0.198 | 1.000 | |
| TB1 specific CD8 T cells | Any cytokines | 3 (21) |
4 (28) |
4 (33) |
6 (50) |
3 (23) |
5 (38) |
0.811 | 0.552 |
| IFN-γ | 3 (21) |
4 (28) |
4 (33) |
6 (50) |
3 (23) |
5 (38) |
0.811 | 0.552 | |
| TNF-α | 0 (0) |
0 (0) |
1 (8) |
0 (0) |
0 (0) |
2 (15) |
0.308 | 0.194 | |
| IL-2 | 0 (0) |
1 (7) |
1 (8) |
2 (17) |
1 (8) |
2 (15) |
0.528 | 0.716 | |
| TB2 specific CD8 T cells | Any cytokines | 2 (14) |
4 (28) |
4 (33) |
8 (67) |
4 (30) |
6 (46) |
0.481 | 0.160 |
| CD4 IFN-γ | 2 (14) |
4 (28) |
4 (33) |
8 (67) |
4 (31) |
5 (38) |
0.481 | 0.145 | |
| TNF-α | 0 (0) |
1 (7) |
1 (8) |
2 (17) |
2 (15) |
4 (31) |
0.393 | 0.291 | |
| IL-2 | 0 (0) |
1 (7) |
0 (0) |
2 (17) |
1 (8) |
1 (8) |
0.641 | 0.668 | |
T0, before TB therapy; T1, after TB therapy; N, Number; *Fisher Test.