Table 3. Hazard Ratios Per 1 SD Increment (95% CI) of Cancer Incidence of UA, Albumin, and Total Bilirubin within the Normal Range.
UA | Albumin | Total bilirubin | |||||
---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | ||
Cancer incidence (n=1348) | 1.04 (0.98–1.10) | 1.02 (0.96–1.08) | 0.93 (0.89–0.98) | 0.93 (0.88–0.98) | 0.94 (0.89–1.00) | 0.95 (0.90–1.00) | |
Stomach (n=250) | 0.95 (0.83–1.09) | 0.93 (0.81–1.07) | 0.99 (0.88–1.12) | 0.97 (0.86–1.10) | 0.91 (0.80–1.03) | 0.92 (0.81–1.05) | |
CRC (n=197) | 1.14 (0.98–1.34) | 1.13 (0.96–1.32) | 1.03 (0.90–1.19) | 1.00 (0.87–1.15) | 0.88 (0.76–1.01) | 0.89 (0.77–1.03) | |
Lung (n=198) | 0.91 (0.78–1.06) | 0.94 (0.81–1.10) | 0.83 (0.72–0.96) | 0.82 (0.72–0.94) | 0.85 (0.74–0.98) | 0.89 (0.77–1.03) | |
Thyroid (n=123) | 1.07 (0.86–1.33) | 1.01 (0.80–1.26) | 1.01 (0.84–1.21) | 1.07 (0.89–1.28) | 1.06 (0.88–1.27) | 1.05 (0.87–1.27) | |
Prostate (n=83) | 1.26 (0.99–1.59) | 1.23 (0.97–1.57) | 1.06 (0.86–1.30) | 1.07 (0.86–1.32) | 1.09 (0.89–1.34) | 1.08 (0.87–1.33) | |
Liver (n=69) | 1.03 (0.79–1.33) | 0.99 (0.76–1.29) | 0.54 (0.43–0.68) | 0.53 (0.42–0.66) | 1.16 (0.92–1.46) | 1.19 (0.94–1.50) | |
Breast (n=49) | 1.06 (0.75–1.50) | 0.96 (0.67–1.38) | 1.07 (0.81–1.43) | 1.06 (0.79–1.43) | 1.34 (1.02–1.77) | 1.27 (0.95–1.70) | |
Others (n=379) | 1.09 (0.97–1.22) | 1.07 (0.95–1.20) | 1.00 (0.91–1.11) | 0.99 (0.89–1.10) | 0.89 (0.81–0.99) | 0.89 (0.80–0.99) | |
Cancer death (n=509) | 0.99 (0.90–1.08) | 1.01 (0.91–1.11) | 0.89 (0.82–0.97) | 0.88 (0.80–0.95) | 0.87 (0.79–0.95) | 0.89 (0.82–0.98) |
SD, standard deviation; CI, confidence interval; UA, uric acid; N, number of cancer incidence or deaths; CRC, colorectal cancer.
Model 1 was adjusted for age and sex. Model 2 was adjusted for age, sex, smoking, alcohol drinking, physical activity, education levels, body mass index, family history of diabetes, and serum high density lipoprotein cholesterol levels.