TABLE 1.
Effect of physical activity on neurogenesis and cognitive function after stroke.
| References | Model | Physical activity | Histological and functional outcome |
| Komitova et al., 2002 | MCAO | 4 weeks enriched environment starting 1 or 7 days after stroke induction | Increase in the number of astrocytes rather than number of neurons Cognition and sensorimotor function were not studied |
| Briones et al., 2005 | 4-vessel occlusion and reperfusion | 2 weeks treadmill running starting 3 days after stroke induction | No change in neurogenesis (BrdU+NeuN+ cells) Cognition and sensorimotor function were not studied |
| Yagita et al., 2006 | 4-vessel occlusion and reperfusion | 3 weeks voluntary running starting 7 days after stroke induction | Decrease in BrdU+ cells Cognition and sensorimotor function were not studied |
| Luo et al., 2007 | MCAO | 4 weeks forced swimming or voluntary running starting 7 days after stroke induction | Forced swimming: decrease in cell proliferation and improved spatial memory Voluntary running: increased BrdU+ cells and improved spatial memory |
| Wurm et al., 2007 | Photothrombotic stroke | Skilled reaching training or enriched environment staring 1 day after stroke induction | Skilled reaching training: increased neurogenesis (BrdU+NeuN+ cells) and improved spatial memory and motor function Enriched environment: increased neurogenesis (BrdU+NeuN+ cells) and improved spatial memory and motor function |
| Geibig et al., 2012 | Photothrombotic stroke | 5 weeks enriched environment or voluntary running starting directly after stroke induction | Increased neurogenesis (BrdU+NeuN+ cells) Improved spatial learning |
| Woitke et al., 2017 | MCAO | 7 weeks voluntary running starting directly after stroke induction | Aberrant neurogenesis (GFP-retrovirus) Impaired spatial memory No benefit of increased neurogenesis (EdU+NeuN+ cells) |
| Cuartero et al., 2019 | MCAO | 3 weeks voluntary running starting 7 days after stroke induction | Increased Ki 67+ and DCX+ cells Aberrant neurogenesis (GFP-retrovirus) Impaired spatial/contextual memory Memory improved upon pharmacological/genetical reduction of post-stroke neurogenesis (DCX+) |
| Sun et al., 2019 | MCAO | 4 weeks treadmill training starting 3 days after stroke induction | Enhanced neural stem/progenitor cell proliferation, differentiation, and migration Improved sensorimotor and cognitive function |
| Zhai and Feng, 2019 | MCAO | 3 weeks constraint-induced movement therapy starting 7 days after stroke induction | Increased neurogenesis (BrdU+NeuN+ cells) Improved spatial learning |
| Codd et al., 2020 | Unilateral hippocampal injury using vasoconstrictor endothelin-1 | 21 days voluntary running starting 8 days after stroke induction | Increased DCX+ cells Improved spatial learning |
| Hong et al., 2020 | Photothrombotic stroke | 28 days treadmill training starting 1 day after stroke induction | Increased neurogenesis (BrdU+DCX+ cells) Improved both short memory and motor function |