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. 2021 Aug 10;12:716625. doi: 10.3389/fendo.2021.716625

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Copyright © 2021 Tahbaz and Yoshihara

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Strategies for immune protection of hPSC derived islets. To protect the transplanted hPSC derived islets graft: 1. Immunosuppressants, 2. Macro encapsulation devices (e.g. Theracyte Device), 3. Micro encapsulation gels (e.g. Alginate-coating), 4. MHC-matching, 5. Genome engineering of immune checkpoint molecules and/or HLAs, 6. Induction of immune tolerance by preconditioning or trained immunity.