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. 2021 May 11;38(9):3754–3774. doi: 10.1093/molbev/msab146

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© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 9. — Summary of main results about halobacterial MalDH evolution. Left: schematic phylogenetic relationships among MalDH within Halobacteria. A–C refer to the various groups. Stars and circles correspond ancestral or modern MalDHs, respectively. The number of amino acid replacements accumulated since LCAHa Anc78 MalDH is indicated within each enzyme. Molecular properties of MalDHs: observed (+), absent (–), or not determined (ND). ND1 refers to refolding problems and ND2 to not done or failed experiments. Data on H. mari MalDH are obtained from Ebel et al. (1999) and Madern and Zaccai (1997). (*) Data obtained from halohandbook: https://haloarchaea.com/halohandbook/.